The effects of mesenchymal stem cells on the structure and contractile force of the carotid artery in a rat aneurysm model

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ATALAY Ö., SEVİM H., KARAHİSAR TURAN S., ONUR M. A., GÜRPINAR Ö. A.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.5, ss.1634-1641, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1701-183
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1634-1641
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model.