The effects of mesenchymal stem cells on the structure and contractile force of the carotid artery in a rat aneurysm model


ATALAY Ö. , SEVİM H. , KARAHİSAR TURAN S. , ONUR M. A. , GÜRPINAR Ö. A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.5, pp.1634-1641, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1701-183
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1634-1641

Abstract

Background/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model.