Leukocytoclastic vasculitis as a previously unreported paraneoplastic manifestation of acute lymphoblastic leukemia in adults

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Ismayilov R., Haziyev T., Ozdemir D. A., Saglam A., BÜYÜKAŞIK Y.

JOURNAL OF HEMATOPATHOLOGY, cilt.13, sa.4, ss.265-268, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s12308-020-00416-6
  • Dergi Adı: JOURNAL OF HEMATOPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Sayfa Sayıları: ss.265-268
  • Anahtar Kelimeler: ALL, Leukocytoclastic vasculitis, Cutaneous vasculitis, Paraneoplastic syndrome, CUTANEOUS VASCULITIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background Although leukocytoclastic vasculitis (LCV) is often idiopathic or secondary to benign diseases, it sometimes accompanies malignancies. Besides being more common in hematological cancers compared to solid tumors, the association of acute lymphoblastic leukemia (ALL) with LCV is extremely rare. Case report In this study, we present a 22-year-old woman presenting with palpable petechiae, purpura, and ecchymoses on her limbs. Bone marrow and skin biopsy of the patient with bicytopenia revealed precursor B cell ALL and LCV, respectively. Conclusion This case is the first adult ALL case with paraneoplastic LCV. In this study, it is emphasized that hematological malignancies should be considered in patients presenting with cutaneous vasculitis, especially in the presence of cytopenia.