To compare an Er:YAG laser-activated bleaching system with different light-activated in-office bleaching systems for color change, surface roughness, and post-bleaching enamel bond strength. 51 enamel slabs were prepared from the sound buccal enamel of extracted bovine teeth. The teeth were randomly divided into three groups according to different light-activated office bleaching systems (n=17): diode laser (Epic, Biolase) (940nm, 7W, continuous mode), Er:YAG laser (LightWalker, Fotona) (2940nm, 50mJ, 10Hz, 1000s), and LED (Radii Plus) (440-480nm, 1500mW/cm(2)). All systems were used with their compatible bleaching agents according to manufacturers' recommendations. The tooth color and surface roughness (Ra) were assessed at baseline and after bleaching using a spectrophotometer and a surface profilometer, respectively. The color change was determined by the CIE L*a*b* system (E, L*, a*, b*). Kruskal-Wallis test was used for color change whereas Kruskal-Wallis and Wilcoxon tests were used to analyze the roughness data. For shear bond strength test (SBS), composite cylinders were bonded on bleached enamel samples 14days after bleaching procedures and stored in water (37 degrees C). Specimens were then debonded with a universal testing machine at 1mm/min and data were analyzed by using Kruskal-Wallis test. All the tested bleaching systems were effective on color change (E>3.3) and produced similar color change (p>0.05). There were no significant differences among the Ra values of the groups neither at baseline nor after bleaching (p>0.05). However, comparing the baseline and after bleaching Ra values, a significant increase was observed for all tested groups (p<0.05). Significant differences were also found among all systems for SBS (p<0.05). The highest values were obtained in Er:YAG group, whereas the LED group revealed the lowest values (p<0.05). All tested bleaching systems were effective on tooth whitening, whereas they all led to an increase on surface roughness. Although the current Er:YAG laser-activated bleaching system did not differ from other tested bleaching systems according to color change and surface roughness, it appears to provide better results in terms of SBS.