Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo

Boddapati S. V., D'Souza G. G. M., Erdogan S., Torchilin V. P., Weissig V.

NANO LETTERS, cilt.8, sa.8, ss.2559-2563, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 8
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1021/nl801908y
  • Dergi Adı: NANO LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2559-2563
  • Hacettepe Üniversitesi Adresli: Evet

Özet

To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to the subcellular site of action. We show here that surface modification of nanocarriers with mitochondriotropic triphenylphosphonium cations facilitates the efficient subcellular delivery of a model drug to mitochondria of mammalian cells and improves its activity in vitro and in vivo.