Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

KAZKAYASI, İNCİ; Ismail, Muhammad-Al-Mustafa; Parrado-Fernandez, Cristina; Bjorkhem, Ingemar; PEKİNER, CAN; Uma, Serdar; Cedazo-Minguez, Angel; Burul-Bozkurt, Nihan

doi:10.1016/j.neulet.2016.09.018

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

Atıf İçin Kopyala

KAZKAYASI İ., Ismail M., Parrado-Fernandez C., Bjorkhem I., PEKİNER C., Uma S., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.633, ss.174-181, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 633
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.neulet.2016.09.018
Dergi Adı: NEUROSCIENCE LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.174-181
Hacettepe Üniversitesi Adresli: Evet

Özet

Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet.