Poly(butylene adipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses


Arslan A., Çakmak S., Cengiz A., Gümüşderelioğlu M.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, vol.27, pp.1841-1859, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2016
  • Doi Number: 10.1080/09205063.2016.1239945
  • Journal Name: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1841-1859
  • Keywords: Poly(butylene adipate-co-terephthalate), scaffold, bone tissue engineering, electrospinning, solvent casting-particulate leaching, melt molding-particulate leaching, BIODEGRADATION, ELECTROSPUN, POLYESTERS, COPOLYESTERS, DEGRADATION, ADHESION

Abstract

The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i.e. solvent evaporation, electrospinning, solvent casting-particulate leaching (SCPL) and melt molding-particulate leaching. The results of physicochemical characterizations and cell culture studies with MC3T3-E1 preosteoblasts confirmed that neat PBAT has favorable characteristics for bone tissue engineering, however, fabrication method strongly affects the cellular responses. Regarding to the characterizations and cell cultures, PBAT scaffolds produced by SCPL and electrospinning are proposed to be used for bone tissue engineering.