Synthesis of New 2-(N'-Allylidene-hydrazino) quinazolinones and 2-(4,5-Dihydropyrazolyl)-quinazolinones and Their Antimicrobial and Antifungal Activity Screening

SAYGILI, NEZİRE; EKİZOĞLU, MELİKE; ERDOĞDU, CEREN

doi:10.14233/ajchem.2014.15880

Synthesis of New 2-(N'-Allylidene-hydrazino) quinazolinones and 2-(4,5-Dihydropyrazolyl)-quinazolinones and Their Antimicrobial and Antifungal Activity Screening

SAYGILI N., EKİZOĞLU M., ERDOĞDU C.

ASIAN JOURNAL OF CHEMISTRY, cilt.26, sa.11, ss.3197-3203, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 11
Basım Tarihi: 2014
Doi Numarası: 10.14233/ajchem.2014.15880
Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3197-3203
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Novel 2-[N'-(1,3-disubstituted-phenyl) allylidene] hydrazine-3-ethyl-3H-quinazolin-4-one (8) and 2-(3,5-disubstituted-phenyl-4,5-dihydropyrazol- 1-yl)-3-ethyl-3H-quinazolin-4-one (9) compounds have been prepared and tested for antibacterial and antifungal activities. 1 H NMR, 13 C NMR, elemental analysis and mass spectroscopy methods have been used to identify molecular structures of the newly synthesized compounds. For screening antibacterial and antifungal activities of the new compounds, minimum inhibitory concentration (MIC) values were evaluated against the Staphylococcus aureus, Escherichia. coli, Pseudomonas aeruginosa, Enterococcus faecalis, Candida albicans, Candida parapsilosis and Candida krusei using microdilution broth method. Compounds 8a-8h exhibited the best antibacterial activity against E. faecalis.