Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus


Batu E. D. , Koşukcu C., Taşkıran E., Sahin S., Akman S., Sözeri B., ...More

JOURNAL OF RHEUMATOLOGY, vol.45, no.12, pp.1671-1679, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.3899/jrheum.171358
  • Journal Name: JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1671-1679
  • Keywords: EARLY-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS, MONOGENIC, COMPLEMENT SYSTEM, WHOLE EXOME SEQUENCING, HUMAN C1Q DEFICIENCY, MOLECULAR-BASIS, SUSCEPTIBILITY VARIANTS, CLINICAL PRESENTATION, C-CHAINS, A-CHAINS, GENES, IDENTIFICATION, ASSOCIATION, VALIDATION

Abstract

Objective. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. Early-onset, familial, and/or syndromic SLE may reveal monogenic pathologies. The aim of this study was to examine genetic associations in patients with early-onset or familial SLE.