The role of CD14 gene promoter polymorphism in tuberculosis susceptibility

Ayaslioglu E., Kalpaklioglu F., Kavut A. B., ERTÜRK A., ÇAPAN N., BİRBEN E.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, cilt.46, sa.3, ss.158-163, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jmii.2012.05.008
  • Dergi Adı: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.158-163
  • Anahtar Kelimeler: CD14, polymorphism, soluble CD14, tuberculosis, CIRCULATING SOLUBLE CD14, PULMONARY TUBERCULOSIS, SERUM CONCENTRATIONS, INNATE IMMUNITY, SEPTIC SHOCK, INFECTION, DISEASE, SEPSIS, BRUCELLOSIS, ELEVATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population.