Elevated M2-muscarinic and beta 1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation

Yalcin M. U., GÜRSES K. M., KOÇYİĞİT D., KESİKLİ S. A., Ates A. H., EVRANOS B., ...More

CLINICAL RESEARCH IN CARDIOLOGY, vol.104, no.3, pp.226-233, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1007/s00392-014-0776-1
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.226-233
  • Hacettepe University Affiliated: Yes


Pathophysiologic mechanisms underlying lone atrial fibrillation (AF) have not been clearly demonstrated yet. Emerging evidence has indicated that autoimmunity may play a role in the development of AF. Relationship between serum anti-M2-muscarinic receptor autoantibody (anti-M2-R) and anti-beta 1-adrenergic receptor autoantibody (anti-beta 1-R) levels and lone paroxysmal atrial fibrillation (PAF) has not been investigated. We aimed to compare anti-M2-R and anti-beta 1-R levels between lone PAF patients and healthy control subjects.