Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters

HAFIZOĞLU M., Eren F., Neşelioğlu S., ŞAHİNER Z., KARADUMAN D., ATBAŞ C., ...More

European Geriatric Medicine, vol.15, no.2, pp.423-434, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.1007/s41999-023-00911-w
  • Journal Name: European Geriatric Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.423-434
  • Keywords: Anti-oxidant, Frailty, Older patients, Oxidative stress
  • Hacettepe University Affiliated: Yes


Aim: To evaluate relationship between frailty and oxidative stress through thiol/disulfide homeostasis parameters [Native thiol (NT), total thiol (TT), and disulfide levels (D), disulfide–native thiol (D/NT), disulfide–total thiol (D/TT), native thiol–total thiol (NT/TT) ratios, and ischemia-modified albumin levels (IMA)]. Materials and methods: In total, 139 community-dwelling older adults were included. The frailty status, defined by the FRIED frailty index (FFI) and Clinical Frailty Scale (CFS), and comprehensive geriatric assessment results compared with thiol/disulfide homeostasis parameters and ischemia-modified albumin levels. Results: NT and TT levels were significantly lower in the frail group (respectively; p = 0.014, p = 0.020). The FFI scores were correlated with the levels of NT, TT, D/NT, D/TT, and NT/TT (respectively; r = − 0.25, r = − 0.24, r = 0.17, r = 0.17, r = − 0.17). The significant correlation could not be retained with the CFS scores. In ROC analysis, the AUC for NT was calculated as 0.639 in diagnosing frailty according to the FFI (95% CI 0.542–0.737), AUC was 0.638 for TT (95% CI 0.540–0.735), and AUC was 0.610 for NT/TT (95% CI 0.511–0.780). The AUC was calculated as 0.610 for both D/NT and D/TT in diagnosing physical frailty (95% CI 0.511–0.708). Conclusion: Thiol/disulfide homeostasis parameters can be a potential biomarker in diagnosing physical frailty. However, further studies are needed for diagnosing frailty defined with cumulative deficit models.