Akademik Veri Yönetim Sistemi
Journal of Pulmonary & Respiratory Medicine, cilt.5, sa.4, ss.277-279, 2015 (Hakemli Dergi)
Common variable immunodeficiency(CVID) is a type of primary humoral immunodeficiency which is generally
diagnosed at childhood. Recurrent sinopulmonary infections are early presentations of disease. Some of the patients
are diagnosed in adulthood. In addition to frequent infections, autoimmune phenomena may occur in about 22% of
patients. Most common autoimmune findings are autoimmune rombocytopenic purpura, hemolytic anemia rheumatoid
arthritis and sicca syndrome. Splenomegaly, granulomatous infiltrations, lymphadenopathy may be seen in the course
of the disease. Increased risk of malignancies is reported in CVID. Hodgkin lymphoma, most common, intestinal
and uterine adeno carcinoma and rarely neuroendocrine tumors are reported with CVID. We report a 65 year-old
woman who had diagnosed as rheumatoid artritis, Sjogren syndrome and idiopathic thrombocytopenic purpura. She
wasdiagnosed as CVID at the age of 65. After IVIG therapy, rheumatologic diseases had stabile course, but she was
diagnosed lung adenocarcinoma 3 year after her diagnosis.