Bone Morphogenetic Protein-7 Enhances Cementoblast Function In Vitro

HAKKI S., Foster B. L., Nagatomo K. J., Bozkurt S. B., HAKKI E. E., Somerman M. J., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.81, sa.11, ss.1663-1674, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1902/jop.2010.100074
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1663-1674
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Bone morphogenetic protein (BMP)-7 is a potent bone-inducing factor and was shown to promote periodontal regeneration in vivo and in vitro; however, to our knowledge, the specific effect of BMP-7 on cementoblasts has not been defined. We aimed to investigate the effects of BMP-7 on cementoblasts, which are cells responsible for tooth root-cementum formation. We hypothesized that BMP-7 would regulate mineralized tissue-associated genes in cementoblasts and influence the expression profile of genes associated with cementoblast extracellular matrix (ECM) and cell adhesion molecules (CAMs).