Bone Morphogenetic Protein-7 Enhances Cementoblast Function In Vitro


HAKKI S., Foster B. L. , Nagatomo K. J. , Bozkurt S. B. , HAKKI E. E. , Somerman M. J. , ...More

JOURNAL OF PERIODONTOLOGY, vol.81, no.11, pp.1663-1674, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1902/jop.2010.100074
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1663-1674

Abstract

Background: Bone morphogenetic protein (BMP)-7 is a potent bone-inducing factor and was shown to promote periodontal regeneration in vivo and in vitro; however, to our knowledge, the specific effect of BMP-7 on cementoblasts has not been defined. We aimed to investigate the effects of BMP-7 on cementoblasts, which are cells responsible for tooth root-cementum formation. We hypothesized that BMP-7 would regulate mineralized tissue-associated genes in cementoblasts and influence the expression profile of genes associated with cementoblast extracellular matrix (ECM) and cell adhesion molecules (CAMs).