7-Substituted Hexahydroquinoline Derivatives and their Calcium Channel Modulator Effects

GÜNDÜZ M. G., Celebi S., Kaygisiz B., ŞİMŞEK R., Erol K., Safak C.

LATIN AMERICAN JOURNAL OF PHARMACY, vol.28, no.6, pp.922-926, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2009
  • Journal Name: LATIN AMERICAN JOURNAL OF PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.922-926
  • Hacettepe University Affiliated: Yes

Abstract

In this study, calcium antagonistic activity of sixteen hexahydroquinoline derivatives have been elucidated in rat ileum and rat thorasic aorta. In the studies on isolated rat ileum, it has been observed that all compounds showed meaningfull activity. In rat thorasic aorta studies, compound 3a has been found more active than nicardipine.