Microwave-assisted synthesis and myorelaxant activity of 9-indolyl-1,8-acridinedione derivatives

GÜNDÜZ M. G., Isli F., El-Khouly A., Yildirim S., Fincan G. S. O., ŞİMŞEK R., ...More

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.75, pp.258-266, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75
  • Publication Date: 2014
  • Doi Number: 10.1016/j.ejmech.2014.01.059
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.258-266
  • Keywords: Acridinedione, Myorelaxant activity, Potassium channel, Pinacidil, POTASSIUM CHANNEL OPENERS, VASCULAR SMOOTH-MUSCLE, BLADDER CONTRACTIONS, ION CHANNELS, 1,1-DIOXIDE A-278637, ORGANIC-SYNTHESIS, PHARMACOLOGY, CALCIUM, 1,4-DIHYDROPYRIDINES, DIHYDROPYRIDINES
  • Hacettepe University Affiliated: Yes

Abstract

In this study a microwave-assisted method was applied for the synthesis of novel 9-(substituted indolyl)-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione derivatives. The structures of the compounds were confirmed by spectral methods including X-ray studies and elemental analysis.