Organelle Positioning in Neurons and Skeletal Muscle Cells

AKSU MENGEŞ E., KURAL MANGIT E., Bekircan-Kurt C. E., BORA G.

GAZI MEDICAL JOURNAL, cilt.32, ss.341-347, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 32
  • Basım Tarihi: 2021
  • Doi Numarası: 10.12996/gmj.2021.79
  • Dergi Adı: GAZI MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.341-347
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Organelles are dynamic compartments, whose spatial positions are tightly regulated for cellular functions. An increasing number of studies have shown dysregulations in organelle positions, especially in muscular and neurological diseases, therefore understanding the basic mechanisms of organelle positioning could help to develop new therapeutic strategies. In this review, we focused on the mechanisms of organelle positioning in two specialized cells, muscle and nerve, as well as the contribution of mispositioning to disease pathomechanisms.