Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue-engineering scaffolds

Inci, Ilyas; Kirsebom, Harald; Galaev, Igor; Mattiasson, Bo; Piskin, PETEK

doi:10.1002/term.1464

Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue-engineering scaffolds

Atıf İçin Kopyala

Inci I., Kirsebom H., Galaev I. Y., Mattiasson B., Piskin E.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, cilt.7, sa.7, ss.584-588, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 7
Basım Tarihi: 2013
Doi Numarası: 10.1002/term.1464
Dergi Adı: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.584-588
Hacettepe Üniversitesi Adresli: Evet

Özet

Gelatin-based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA-containing cryogels were 18.5 +/- 3.0 kPa, which is suitable for non-load-bearing bone tissue-engineering (TE) applications, especially for the craniofacial area. Copyright (c) 2012 John Wiley & Sons, Ltd.