Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods

AKDAĞ ÇAYLI Y., GÜLSÜN İNAL T., İZAT N., ÇETİN M., ÖNER L., ŞAHİN S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.57, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jddst.2020.101760
  • Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE
  • Anahtar Kelimeler: Fast disintegrating tablets, Deferasirox, Direct compression, Lyophilization, Permeability, IN-VITRO PERMEABILITY, ABSORPTION, FORMULATION, FORMS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although there are conventional oral tablets and tablets for oral suspension of deferasirox in the market, deferasirox oral FDTs are not yet available in the market and under investigation.