Therapeutic efficacy of folate receptor-targeted amphiphilic cyclodextrin nanoparticles as a novel vehicle for paclitaxel delivery in breast cancer

ERDOĞAR N., ESENDAĞLI G., Nielsen T. T., Esendagli-Yilmaz G., Yoyen-Ermis D., Erdogdu B., ...Daha Fazla

JOURNAL OF DRUG TARGETING, cilt.26, sa.1, ss.66-74, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/1061186x.2017.1339194
  • Dergi Adı: JOURNAL OF DRUG TARGETING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.66-74
  • Anahtar Kelimeler: Paclitaxel, nanoparticle, folate, amphiphilic cyclodextrin, breast cancer, IN-VIVO EVALUATION, DRUG-DELIVERY, CARBON NANOTUBES, TAXOL, FORMULATION, CELLS, VITRO, RELEASE, CAMPTOTHECIN, CHEMOTHERAPY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study is to test folate-conjugated cyclodextrin nanoparticles (FCD-1 and FCD-2) as a vehicle for reducing toxicity and increasing the antitumor efficacy of paclitaxel especially for metastatic breast cancer.