First report of t(1;9)(q21;q34) in Fanconi anemia as a preceeding chromosomal aberration before leukemia development
KUWAIT MEDICAL JOURNAL, cilt.54, sa.1, ss.119-122, 2022 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 1
- Basım Tarihi: 2022
- Dergi Adı: KUWAIT MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), EMBASE
- Sayfa Sayıları: ss.119-122
- Anahtar Kelimeler: acute myeloid leukemia, childhood leukemia, chromosomal abnormalities, Fanconi anemia, rare translocation, ACUTE MYELOID-LEUKEMIA, ABNORMALITIES, MALIGNANCIES, RISK, AML
- Hacettepe Üniversitesi Adresli: Evet
Özet
Patients with Fanconi anemia (FA) tend to develop various hematologic and solid tumors. Cytogenetic abnormalities such as translocations of chromosome 1q, monosomy 5 and 7, trisomy 10, gains of 3q and t(8;21) have been reported in patients with FA who developed hematological malignancies. Since survival is low after the development of leukemia in FA patients, the follow-up for leukemia progression is very important. For this reason, cytogenetic anomalies that can be used as biomarkers in the development of leukemia are needed. Herein, we describe a patient with FA who developed acute myeloid leukemia with der(9)t(1;9) (q21;q34) for the first time.