Association between early chronic methicillin-susceptible Staphylococcus aureus colonization and lung function in children with cystic fibrosis

Sunman B., Yalcin E., Ozsezen B., Tural D. A., Buyuksahin H. N., Guzelkas I., ...More

PEDIATRIC PULMONOLOGY, vol.57, no.12, pp.2963-2970, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 12
  • Publication Date: 2022
  • Doi Number: 10.1002/ppul.26114
  • Journal Name: PEDIATRIC PULMONOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.2963-2970
  • Keywords: children, colonization, cystic fibrosis, lung function, MSSA, YOUNG-CHILDREN, STREPTOCOCCUS-PNEUMONIAE, FUNCTION DECLINE, INFANTS, INFLAMMATION, INFECTION, PSEUDOMONAS, PREVALENCE, GUIDELINES, AIRWAYS
  • Hacettepe University Affiliated: Yes

Abstract

Background Our aim was to determine whether early chronic methicillin-susceptible Staphylococcus aureus (MSSA) colonization in children with cystic fibrosis (CF) is associated at 8 years of age with poorer lung function, poorer nutritional status, and increased exacerbation frequency. Methods In this retrospective cohort study, a total of 52 children with chronic MSSA colonization were included. Of them, 26 were chronically colonized with MSSA before the age of 4 years (early onset), and 26 were chronically colonized from 4 years to 6 years of age (late-onset). At the age of 8 years, lung function, body mass index (BMI) as an indicator of nutritional status and frequency of pulmonary exacerbations were compared between two groups. Results At 8 years of age, BMI was similar between the early-onset and late-onset groups (15.0 [min-max: 12.9-26.8] vs. 15.7 (min-max: 13.0-24.9), p = 0.327]. Percentage of forced expiratory volume in 1 s (FEV1) and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) in 8-year-old children were significantly lower in the early onset group compared to the late-onset group (98 [min-max: 44-139] vs. 106.5 [min-max: 82-131], p = 0.047; 84.9 +/- 25.5 vs. -102.3 +/- 26.3, respectively; p = 0.019], although the percentage of forced vital capacity did not differ significantly between two groups (93.5 [min-max: 45-131] vs. 103 [min-max: 84-119], respectively; p = 0.092). Exacerbation frequency between the ages of 6 and 8 years in the early onset group was higher compared to the late-onset group according to the Poisson regression model [1 (min-max:0-10) vs 0 (min-max:0-4), respectively; p = 0.044]. Conclusions Early chronic MSSA colonization is associated with poorer lung function and frequent exacerbations in children with CF. However, further studies are needed to reveal the cause-and-effect relationship between early chronic MSSA colonization and pulmonary outcome.