Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study


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Salomaa V., Pankow J., Heiss G., Cakir B., Eckfeldt J., Ellison R., ...More

JOURNAL OF INTERNAL MEDICINE, vol.247, no.6, pp.689-698, 2000 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 247 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1046/j.1365-2796.2000.00682.x
  • Journal Name: JOURNAL OF INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.689-698

Abstract

Objectives. To examine the prevalence of four mutations, T59G, T1067A, T202C and C314T, of the human alpha(1,3/1,4) fucosyltransferase 3 (FUT 3) gene amongst persons with Lewis negative and those with Lewis positive blood group phenotype. An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction.