Akademik Veri Yönetim Sistemi
Molecular biology in Psychiatric Disorders, Şefik Güran, Editör, Türkiye Klinikleri, Ankara, ss.65-72, 2024
Psychiatric diseases, which affect a large part of the world population, are a heterogeneous group of diseases that are difficult to model due to their complex etiologies; therefore, the pathogenesis of the disease is not fully understood. Because of the neuroanatomical and species-specific differences between animal models and humans, the information obtained from these models cannot be successfully transferred to the clinic. While advances in genetics and technology enable the identification of several risk variants that predispose to the disease, patient-derived models created using stem cell biology and genome editing tools make a great contribution to investigating the functional effects of these variants and filling the translational gap in psychiatric disease studies. In this section, models used in psychiatric disease research and their limitations are discussed in detail with regard to IPSC technology.