Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Ogishi M., Yang R., Aytekin C., Langlais D., Bourgey M., Khan T., ...More

NATURE MEDICINE, vol.27, no.9, pp.1646-1680, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1038/s41591-021-01388-5
  • Journal Name: NATURE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database, DIALNET
  • Page Numbers: pp.1646-1680
  • Hacettepe University Affiliated: Yes


Dysregulated immune features in a patient with a homozygous loss-of-function mutation in PDCD1 suggest that IL-6, IL-23, STAT3 and ROR gamma T might be potential targets for treatment of PD-1 blockade-induced autoimmunity.