Dual inhibition of the epidermal growth factor and vascular endothelial growth factor phosphorylation for antivascular therapy of human prostate cancer in the prostate of nude mice

Yazici S., Kim S., Busby J., He J., Thaker P., Yokoi K., ...Daha Fazla

PROSTATE, cilt.65, sa.3, ss.203-215, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/pros.20283
  • Dergi Adı: PROSTATE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.203-215
  • Anahtar Kelimeler: prostate cancer, EGF-R and VEGF-R phosphorylation, antivascular therapy, RECEPTOR TYROSINE KINASE, CELL LUNG-CANCER, MICROVASCULAR HYPERPERMEABILITY, CLINICAL-SIGNIFICANCE, EGF RECEPTOR, TUMOR-CELLS, EXPRESSION, ANGIOGENESIS, PROGRESSION, BLOCKADE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND. Androgen-independent prostate cancer (PCa) may be susceptible to modulation of the tumor microenvironment. We determined whether a dual tyrosine kinase inhibitor (AEE788) of the epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) combined with chemotherapy can produce therapy of human PCa in nude mice.