In vitro comparison of nanofibrillar and macroporous-spongious composite tissue scaffolds for periodontal tissue engineering

ŞAHBAZOĞLU K. B., DEMİRBİLEK M., BAYARI S., BÜBER E., Toklucu S., TÜRK M., ...More

CONNECTIVE TISSUE RESEARCH, vol.63, no.2, pp.183-197, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1080/03008207.2021.1912029
  • Journal Name: CONNECTIVE TISSUE RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.183-197
  • Keywords: Periodontal tissue engineering, periodontal regeneration, nanocomposite-tissue scaffolds, PLGA tissue scaffolds, PDL cell cultures, OSTEOGENIC DIFFERENTIATION
  • Hacettepe University Affiliated: Yes

Abstract

Purpose/Aim of the study: The ultimate goal of periodontal treatment is to regenerate the lost periodontal tissues. The interest in nanomaterials in dentistry is growing rapidly and has focused on improvements in various biomedical applications, such as periodontal regeneration and periodontal tissue engineering. To enhance periodontal tissue regeneration, hydroxyapatite (HA) was used in conjunction with other scaffold materials, such as Poly lactic-co-glycolic-acid (PLGA) and collagen (C). The main target of this study was to compare the effects of nano and macrostructures of the tissue scaffolds on cell behavior in vitro for periodontal tissue engineering.