The role of SCCA1 in asthma related physiological events in the airway epithelium and the effect of promoter variants on asthma and gene function

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Karaaslan C., BİRBEN E., KESKİN O., Sahiner Ü. M., Sackesen C., KALAYCI O.

RESPIRATORY MEDICINE, vol.107, no.3, pp.368-379, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.rmed.2012.11.003
  • Journal Name: RESPIRATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.368-379
  • Keywords: Apoptosis, Asthma, Cytokine, Mucus, Protease inhibitor, Squamous cell carcinoma antigen, SQUAMOUS-CELL CARCINOMA, ALLERGIC INFLAMMATION, PROTEINASE-INHIBITOR, CHILDHOOD ASTHMA, IL-4 RECEPTOR, ANTIGENS 1, T-CELLS, SERPIN, PROTEASES, TRANSCRIPTION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Even though the systemic level of SCCA1, a serine protease inhibitor, was shown to be elevated in asthma, its physiological role is unknown.