Atrial fibrillation and stroke in the perspective of new oral anticoagulants Yeni̇ anti̇koagülanlar perspekti̇fi̇nde atri̇yal fi̇bri̇lasyon ve i̇nme


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Baş D. F., TOPÇUOĞLU M. A., ARSAVA E. M.

Turk Beyin Damar Hastaliklar Dergisi, cilt.19, sa.2, ss.35-45, 2013 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5505/tbdhd.2013.33042
  • Dergi Adı: Turk Beyin Damar Hastaliklar Dergisi
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.35-45
  • Anahtar Kelimeler: Anticoagulant, Apixaban, Atrial fibrillation, Dabigatran, Rivaroxaban, Stroke, Warfarin
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Atrial fibrillation is an independent, powerful risk factor for stroke. Until recently, acetyl salicylic acid (aspirin) and warfarin were the only approved treatment options for stroke prophylaxis. Although warfarin provides a significantly better risk reduction in stroke compared to placebo and aspirin, its usage difficulties entailed investigation of new treatment alternatives. Studies showed that new oral anticoagulants (such as dabigatran, apixaban and rivaroxaban) are as efficient and safe as warfarin. New anticoagulants seem appealing by their rapid onset of action and low drug and diet interactions, together with not necessitating any routine monitoring; however lack of specific antidotes constitute a disadvantage at the moment.