Urinary profile of 6 beta-hydroxycortisol in workers exposed to aluminum


Baydar T. , Aydin A. , Sahin G.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.120, pp.36-41, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 120
  • Publication Date: 2007
  • Doi Number: 10.1007/s12011-007-0073-1
  • Title of Journal : BIOLOGICAL TRACE ELEMENT RESEARCH
  • Page Numbers: pp.36-41

Abstract

The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P (450)3A4 by measuring the urinary excretion of 6 beta-hydroxycortisol as biomarker. There is a positive correlation between urinary 6 beta-hydroxycortisol and aluminum excretion (p < 0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P (450) in exposed individuals.