Selective inhibition of nitric oxide synthase causes increased muscle thickness in rat esophagus.

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SOYER T., Boybeyi Ö., Atasoy P.

Journal of pediatric surgery, vol.50, no.7, pp.1112-4, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jpedsurg.2014.10.057
  • Journal Name: Journal of pediatric surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1112-4
  • Hacettepe University Affiliated: Yes


Aim: Achalasia is a primary motor dysfunction of esophagus which can be created experimentally by nitric oxide synthase (NOS) inhibition. Although several theories have been suggested, mechanism of increased esophageal muscle thickness in achalasia is still unclear. An experimental study was performed to evaluate the esophageal muscle thickness after selective inhibition of NOS in rats.