Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats

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Gulsen S., Inci S., Yuruk S., YAŞAR Ü., Ozgen T.

NEUROLOGIA MEDICO-CHIRURGICA, cilt.47, sa.12, ss.537-542, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.2176/nmc.47.537
  • Dergi Adı: NEUROLOGIA MEDICO-CHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.537-542
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.