A Challenging Diagnosis of Homozygous Prekallikrein Deficiency During the Preoperative Evaluation of an Infant With Intractable Seizures: A Literature Review of Surgical Management in This Disorder

ÜNAL S., Jariwala P. D. , Mahoney D. H. , Teruya J.

LABMEDICINE, vol.41, no.5, pp.271-274, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1309/lm5vs8fifrf1ohct
  • Journal Name: LABMEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.271-274


Prekallikrein is 1 of the factors involved in the contact phase of coagulation, and prekallikrein deficiency is characterized with no spontaneous or injury-related bleeding, despite markedly prolonged activated partial thromboplastin time (aPTT). The literature on the management of these patients during preoperative evaluation and delivery to surgery is limited, Herein we present a prekallikrein deficient 14-month-old boy who experienced no bleeding during or after epilepsy surgery with 1 course of fresh frozen plasma prior to surgery.