Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles

Cicek O. S. Y., HEKİMOĞLU E. R., TURĞAL M., ATİLLA P., ÇAKAR A. N., USUBÜTÜN A., ...Daha Fazla

PLACENTA, cilt.69, ss.64-70, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.placenta.2018.07.002
  • Dergi Adı: PLACENTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-70
  • Anahtar Kelimeler: Hydatidiform mole, Leukemia inhibitory factor (LIF), Insulin like growth factor-1 (IGF-1), Decidua, Trophoblast, Immunohistochemistry, HUMAN-PLACENTA, TROPHOBLAST INVASION, FACTOR LIF, FETOMATERNAL INTERFACE, CHORIOCARCINOMA CELLS, HUMAN ENDOMETRIUM, BINDING, IGF, RECEPTOR, BIOSYNTHESIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.