Hemophagocytic lymphohistiocytosis secondary to Varicella zoster infection in a child with Henoch-Schonlein purpura

Gur G., Cakar N., Uncu N., Ayar G., Basaran O., Taktak A., ...More

PEDIATRICS INTERNATIONAL, vol.57, no.2, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1111/ped.12523
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: Yes

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a fatal, hyper-inflammatory syndrome that is characterized by untimely activation of macrophages, and manifests as cytopenia, organ dysfunction, and coagulopathy. Secondary HLH can be associated with infection, drugs, malignancy, and transplantation, and is mostly triggered by infection. Herein, we report the case of a patient with Henoch-Schonlein purpura (HSP) who developed severe HLH secondary to Varicella zoster infection.