Basal Serum Thyroxine Level should Guide Initial Thyroxine Replacement Dose in Neonates with Congenital Hypothyroidism

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GÜNBEY C., Ozon A., GÖNÇ E. N., ALİKAŞİFOĞLU A., KARAHAN S., KANDEMİR N.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.13, no.3, pp.269-275, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.4274/jcrpe.galenos.2020.2020.0194
  • Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.269-275
  • Keywords: Newborn screening, children, congenital hypothyroidism, Na-L thyroxine, dose, THYROID-HORMONE REPLACEMENT, CHILDREN, INFANTS, OVERTREATMENT, LEVOTHYROXINE, THERAPY, TSH
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Initial high-dose sodium levothyroxine (Na-LT 4) (10-15 mu g/kg/day) replacement for primary congenital hypothyroidism (CH) is recommended in guidelines. However, high-dose Na-LT 4 risks iatrogenic hyperthyroidism. The aim of this study was to investigate the normalizing effect of varying initial doses of Na-LT 4 on serum thyroid hormone levels.