Expression Profiles of the Individual Genes Corresponding to the Genes Generated by Cytotoxicity Experiments with Bortezomib in Multiple Myeloma


GHASEMİ m., ALPSOY S., TÜRK TÜRK S., MALKAN Ü. Y. , ATAKAN Ş., HAZNEDAROĞLU İ. C. , ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.33, no.4, pp.286-292, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.4274/tjh.2015.0145
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.286-292
  • Keywords: Myeloma and other plasma cell dyscrasias, Neoplasia, Cytogenetics, Gene therapy, Molecular hematology, COST-EFFECTIVENESS, IN-SILICO, DRUG-SENSITIVITY, CANCER-CELLS, THERAPY, PLASMACYTOMAS, DEXAMETHASONE, LENALIDOMIDE, MALIGNANCIES, SIMULATION

Abstract

Objective: Multiple myeloma (MM) is currently incurable due to refractory disease relapse even under novel anti-myeloma treatment. In silico studies are effective for key decision making during clinicopathological battles against the chronic course of MM. The aim of this present in silico study was to identify individual genes whose expression profiles match that of the one generated by cytotoxicity experiments for bortezomib.