Effect of permeability enhancers on paracellular permeability of acyclovir

Ates M., KAYNAK M. S., ŞAHİN S.

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.68, sa.6, ss.781-790, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/jphp.12551
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.781-790
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir.