An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Jiang Y., Oron T. R., Clark W. T., Bankapur A. R., D'Andrea D., Lepore R., ...Daha Fazla

GENOME BIOLOGY, cilt.17, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1186/s13059-016-1037-6
  • Dergi Adı: GENOME BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Protein function prediction, Disease gene prioritization, DISINTEGRIN, ONTOLOGY, ADAM
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for protein function prediction and tracking progress in the field remain challenging.