Orally disintegrating tablets i: Preparation technologies Aǧizda daǧilan tabletler i: Hazirlama teknolojileri


Ölmez S. S. , VURAL İ. , ŞAHİN S. , ERTUĞRUL A. , ÇAPAN Y.

Hacettepe University Journal of the Faculty of Pharmacy, vol.30, no.2, pp.205-230, 2010 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2010
  • Title of Journal : Hacettepe University Journal of the Faculty of Pharmacy
  • Page Numbers: pp.205-230

Abstract

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Orally disintegrating tablets (ODTs) have gained considerable attention as preferred alternatives to conventional tablet and capsule formulations. ODTs are widely accepted dosage forms, especially for the dysphagic, pediatric, geriatric, psychic and bedridden patients. ODTs are designed to disintegrate or dissolve rapidly on contact with saliva, thus eliminating the need to chew the tablet, swallow an in intact tablet, or take the tablet with liquids. Various scientific techniques including freeze drying, moulding, spray drying, sublimation, direct compression, cotton candy process, mass extrusion, melt granulation, three-dimensional printing have been employed for the development of ODTs. The current article is focused on ideal characteristics, significant features, preparation technologies, formulation aspects including the use of superdisintegrants and taste-masking technologies.