Abietic acid inhibits lipoxygenase activity

Ulusu N., Ercil D. , Sakar M., Tezcan E.

PHYTOTHERAPY RESEARCH, vol.16, no.1, pp.88-90, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1002/ptr.983
  • Title of Journal : PHYTOTHERAPY RESEARCH
  • Page Numbers: pp.88-90


In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC and an IC50 of 29.5 +/- 1.29 muM was determined. Since the lipoxygenase pathway leads to the blosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions. Copyright (C) 2002 John Wiley Sons, Ltd.