Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients

Creative Commons License

Topcu D. B., Tugcu G., ER B., Polat S. E., Hizal M., Yalcin E. E., ...More

Inflammation, vol.45, no.2, pp.627-638, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1007/s10753-021-01572-2
  • Journal Name: Inflammation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.627-638
  • Keywords: Cystic fibrosis, YKL-40, Chitotriosidase activity, Exacerbation, Inflammation, Respiratory function test, PROTEIN YKL-40, INFLAMMATION, DISEASE, STANDARDIZATION, EXACERBATION, SPIROMETRY, BIOMARKER, MARKER, ASTHMA
  • Hacettepe University Affiliated: Yes


© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.We investigated plasma YKL-40 levels and chitotriosidase (CHIT1) activity in patients with cystic fibrosis (CF) lung disease and evaluated clinically relevant factors that may affect their levels. Plasma samples were obtained from pediatric (n = 19) and adult patients (n = 15) during exacerbation, discharge, and stable period of the disease. YKL-40 levels and chitotriosidase activity were measured by enzyme-linked immunosorbent assay and fluorometric assay, respectively. Data were compared with healthy children and adults of similar age. YKL-40 levels of pediatric and adult CF patients at all periods were significantly higher than controls (p < 0.001 and p < 0.05). CHIT1 activities of adult patients at all periods were significantly higher compared to controls (p < 0.05). On the other hand, CHIT1 activities of pediatric CF patients were similar with controls. YKL-40 levels of exacerbation period of adult CF patients were negatively correlated with forced vital capacity (FVC) (r = − 0.800, p = 0.014) and forced expiratory volume in 1 s (FEV1) (r = − 0.735, p = 0.008). YKL-40 levels in the exacerbation period of pediatric CF patients were negatively correlated with FVC (r = − 0.697, p = 0.0082) and FEV1 (r = − 0.720, p = 0.006). CHIT1 activity may be a valuable marker of chronic inflammation in adult CF patients who suffer from CF for a longer period compared to pediatric patients. Increased YKL-40 levels in both pediatric and adult patients compared to controls may point to a role in between CF pathology.