Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain

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Tang J., Postnov D. D., Kilic K., Erdener Ş. E., Lee B., Giblin J. T., ...Daha Fazla

ADVANCED SCIENCE, cilt.7, sa.18, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 18
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/advs.202001044
  • Dergi Adı: ADVANCED SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Compendex, INSPEC, Directory of Open Access Journals
  • Anahtar Kelimeler: brain imaging, cerebral blood flow velocity, field autocorrelation function, functional ultrasound velocimetry, CEREBRAL-BLOOD-FLOW, DOPPLER, ECHOES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.