Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives


Tan O. U. , Ozadali K. , Yesilyurt O., Kayir H., Uzbay T. , BALKAN A.

TURKISH JOURNAL OF CHEMISTRY, vol.35, no.1, pp.121-130, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.3906/kim-1004-584
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.121-130

Abstract

Some isoxazolo[4,5-d]pyridazin4(5H) -one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).

Some isoxazolo[4,5-d] pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).