Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines

Tozkoparan B., ERTAN M., KREBS B., LAGE M., Kelicen P., DEMIRDAMAR R.

ARCHIV DER PHARMAZIE, vol.331, no.6, pp.201-206, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 331 Issue: 6
  • Publication Date: 1998
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.201-206
  • Hacettepe University Affiliated: Yes

Abstract

In this study, thirty six new 2-benzylidene-7-methyl-3-oxo-5-phenyl-2,3 -dihydro-5H-thiazolo [3,2-a]pyrimidine-6-carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carrageenan hind paw edema test. It was found that compound 6a having a 2-methoxyphenyl group at position 5 and a benzylidene group at position 2 was the most potent compound in this series. All the compounds that were tested for ulcer activity gave positive results.