Di (2-etilhekzil) Fitalatın Pubertal Dönemdeki Erkek Sıçanlarda Genotoksik ve Biyokimyasal Etkilerinin Araştırılması

BARLAS N. (Yürütücü)

Yükseköğretim Kurumları Destekli Proje, BAP Araştırma Projesi, 2014 - Devam Ediyor

Proje Türü: Yükseköğretim Kurumları Destekli Proje
Destek Programı: BAP Araştırma Projesi
Başlama Tarihi: Ocak 2014
Bitiş Tarihi: Devam ediyor
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu

Proje Özeti

Today, a large number of chemicals are used in industry, agriculture, house and the other places and people and other living things found in nature, directly or indirectly, exposure to them and as a result of this adverse effects observed. With this man-made or natural chemicals which are known with their endocrine-disrupting effects, there is a major concern in the world. The U.S. Environmental Protection agency identified endocrine disruptors as an environmental health problem. Especially in the 2000s, many studies have been done about them, but they are still not illuminated. Between these chemicals, phthalates are located as used in the production of plastics. When phthalates are unable to connect to plastics, they remain free and organisms expose to them orally, dermally, or during medical procedures. Because of using as a plasticizer in commercial products, food packaging materials, and biomedical instruments, they often observe in food and the environment. Studies show that in drinking water, in the air of in-home and out-of-home, the amount is found quite high. Also, in commercial products, baby bottles, baby toys, packaging of products such as milk, cheese, chips, there is phthalate content. The most products which are used by babies and little children contain phthalates and this increased interest of investigation of the effects of them. DEHP (di-2-ethylhexyl phthalate) is one of the phthalates that found in nature and mostly used by people. In our study, we aim to investigate DEHP (di-2-ethylhexyl phthalate) which has C₆H₄(C₈H₁₇COO)₂ formula. It is viscous and it is insoluble in water and soluble in oil. It is used widely because of its price. People expose to it from food and water. It is used in catheters, syringes, nasogastric tubes, dialysis materials, plastics which blood store in, open air tubes and the other many medical materials. Especially, the studies with dialysis patients showed that DEHP were found highly in their blood. Several studies have been conducted in animals shows that the high rate of accumulated in their body. It is aimed to investigate the possible effects of these endocrine-disrupters which are intensively used and exposured on the rats genotoxically, biochemically and histologically.