Bioguided fractionation of Polygonum alpinum and isolation and structure elucidation of active compounds

Demirezer L. Ö., KURUUZUM-UZ A., GUVENALP Z., SULEYMAN H.

PHARMACEUTICAL BIOLOGY, cilt.44, sa.6, ss.462-466, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/13880200600798544
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.462-466
  • Anahtar Kelimeler: anti-inflammatory activity, flavonol glycosides, Polygonaceae, Polygonum alpinum, radical scavenging effect, FLAVONOIDS, LAPATHIFOLIUM, SENEGALENSE, HYDROPIPER, GLYCOSIDES, CHALCONE, NODOSUM, SSP
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Bioguided fractionation of the methanol extract of aerial parts from Polygonum alpinum L. ( Polygonaceae) was investigated using the exudation phase of inflammation in aseptic arthritis model, which is produced by carrageenan and radical-scavenging properties. Flavonoid-containing fractions showed anti-inflammatory and radical-scavenging activities. Therefore, isolation and structure elucidation of flavonoids were carried out. The eight flavonol glycosides, which were quercetin 3-O-arabinofuranoside (avicularin) (1), quercetin 3-O-beta-glucuronopyranoside (2), quercetin 3-O-alpha-rhamnopyranosyl (1 -> 6)-beta-glucopyranoside (3), quercetin 3-O-beta-galacturonopyranoside (4), quercetin 3-O-beta-glucopyranoside (5), kaempferol 3-O-beta-galactopyranoside (6), quercetin 3-O-beta-galactopyranoside (hyperoside) (7), and myricetin 3-O-beta-galactopyranoside (8), were isolated from the methanol herb extract of Polygonum alpinum. The structures were established by spectroscopic methods.